World Wide Mutant
Summary Mutant for Explorer
Information about orf6
Description
The ORF6 protein disrupts cell nuclear import complex formation via tethering the nuclear import factors Kap?2 and Kap?1 to the ER/Golgi membrane. Retention of import factors at the ER/Golgi membrane, effectively blocking STAT1 transport into the nucleus in response to interferon signaling. Thus, the virion blocked the expression of interferon stimulated genes (ISGs) involved in the multiple antiviral innate immune response.
SequenceMFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID
Length and Mass61 aa; 150 kDa
