World Wide Mutant

Summary Mutant for Explorer

Information about neoclocapsid

Description

The nucleocapsid (N) protein is the most abundant protein produced by the SARS-CoV-2 genome and is a major structural and multifunctional protein. The primary role of the N protein is in the virus replication cycle, by packaging the positive strand viral genome RNA into long, flexible, helical ribonucleoprotein (RNP) complexes through its N-terminal domain (N-NTD), which makes this domain an important drug target. The C-terminal domain of the N protein (N-CTD) is involved in dimerization. N protein also interacts with the viral genome and membrane protein during virion assembly. Plays a critical role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication

Sequence

MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAALALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDDFSKQLQQSMSSADSTQA

Length and Mass

419 aa; 150 kDa

Pie chart

77.4%8.42%6.8%5.38%2.05%
Four Mutants and moreThree MutantsTwo MutantsOne MutantNot MutantWorld Wide

Heat chart

1_4141_8282_123123_164164_205205_246246_287287_328328_369369_410
0.010.02World WideResidue

TimeLine chart

Nov 30, 2019Dec 31, 2019Jan 31, 2020Feb 29, 2020Mar 31, 2020Apr 30, 2020May 31, 2020Jun 30, 2020Jul 31, 2020Aug 31, 2020Sep 30, 2020Oct 31, 2020Nov 30, 2020Dec 31, 2020Jan 31, 2021Feb 28, 2021Mar 31, 2021Apr 30, 2021May 31, 2021Jun 30, 2021Jul 31, 2021Aug 31, 2021Sep 30, 2021Oct 31, 2021Nov 30, 2021Dec 31, 2021Jan 31, 2022Feb 28, 2022Mar 31, 2022Apr 30, 202200.20.40.60.81
R(203)G(204)D(377)D(63)G(215)S(235)D(3)A(220)P(199)M(234)World WideMutation rate

Stack chart

A(220)P(199)Q(9)S(235)D(3)G(204)G(215)D(63)D(377)R(203)00.20.40.60.8
convertedNEGILKMSTWVACQHFYRDPWorld WideResiduesMutant Rate