Description

The NSP15 is a Mn(2+)-dependent, Nidoviral uridylate-specific endoribonuclease (NendoU) that leaves 2'-3'-cyclic phosphates at the 3' terminal end to the cleaved bond and serves as a degrader of viral RNA fragments that may activate the infected cell’s antiviral defenses. The NSP15 has an N-terminal domain, a middle (M) domain, and a C-terminal catalytic (NendoU) domain. The catalytic function of NSP15 resides in the C-terminal NendoU domain.

Sequence

SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ

Length and Mass

346 aa; 150 kDa